Role of Unphosphorylated, Newly Synthesized IkBb in Persistent Activation of NF-kB

Synergistic Activation of NF-kB by Tumor Necrosis Factor Alpha and Gamma Interferon via Enhanced IkBa Degradation and De Novo IkBb Degradation

The effects of labour and of interleukin 1 beta upon the expression of nuclear factor kappa B related proteins in human amnion.

Human labour is associated with persistently increased nuclear factor kappa B (NF-kB) activity in amnion. In this study we have shown that this involves only the p65 and p50 NF-kB subunits and is associated with an increase in the expression of p65 (P < 0.05), and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2 (P < 0.05). Interleukin-1b stimulation leads to rapid degradation and resynthe...

Expression of Constitutively Active IkBb in T Cells of Transgenic Mice: Persistent NF-kB Activity Is Required for T-Cell Immune Responses

Early NF-kB activation is associated with hormone-induced pancreatitis

Gukovsky, Ilya, Anna S. Gukovskaya, Thane A. Blinman, Vjekoslav Zaninovic, and Stephen J. Pandol. Early NF-kB activation is associated with hormone-induced pancreatitis. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1402–G1414, 1998.—Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show that transcription factor nuclear factor-kB (NF-kB), which r...

Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kB (RelAyp50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkBa and IkBb degradation

As previously reported, Listeria monocytogenes infection of P388D1 macrophages results in a rapid induction of NF-kB DNA-binding activity. Here we show that this induction of NF-kB activity occurs in a biphasic mode: first, a transient, IkBa degradation-dependent phase of activity, also induced by the nonvirulent species Listeria innocua, which is mediated by binding of the bacteria to the macr...